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Progressive Retinal Atrophy

Progressive Retinal Atrophy in dogs is commonly known by the abbreviation PRA.

Progressive Retinal Atrophy is an inherited disease that has occurs in most breeds of dogs and also occurs in mixed breeds. It is ‘ recessive’ meaning that the affected dog must have inherited the defective gene from both parents.

Progressive retinal atrophy (PRA) is an eye disease in which the retina degenerates and the affected animal suffers impaired vision –– and often blindness. There are two forms of the disease: generalized progressive retinal atrophy (GPRA) and central progressive retinal atrophy (CPRA); the latter is the less common form. PRA is hereditary, and many breeds of dogs are affected.

Both parents need to carry the affected Gene for the offspring to inherite this disorder.

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Basil’s test results show he is NORMAL/CLEAR

You can therefore be reassured that your Cockapoo puppy will Not be affected with

Progressive Retinal Atrophy(PRA)


VonWillebrands Disease  (blood clotting disorder)

Von Willebrand Disease, also called VWD, is the most common inherited blood clotting disorder in dogs. It’s the result of an insufficient amount of Von Willebrand Factor (VWF), which is a plasma protein that helps blood to clot. VWD can result in excessive, serious bleeding from even a minor skin wound.

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Basil’s Test Results shows he is NORMAL and HEALTHY

You can therefore be reassured that your Cockapoo Puppy will Not be affected with 

VonWillebrand Disease Type 1 (VWD1)


Malignant Hyperthermia

Malignant hyperthermia in dogs is caused by mutation in the ryanodine receptor ( RYR1 gene), due to amino acid exchange in the naturally forming protein. Malignant hyperthermia is an autosomal dominant disease.
Malignant hyperthermia is a life-threatening syndrome, occurring in all breeds of dogs. It is a congenital disorder of skeletal muscle. When there is a significant increase in the dogs temperature. symptoms include accelerated and irregular heart rate , hyperventilation, muscle rigidity which may result in renal failure and death.
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Basil’s Test Results shows he is NORMAL and HEALTHY
You can therefore be reassured that your Cockapoo Puppy will Not be affected with
Canine Malignant Hyperthermia (MH)

Canine degenerative myelopathy (DM)

Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy,
Mutations in canine superoxide  (SOD1) have recently been shown to cause canine degenerative myelopathy, a disabling neurodegenerative disorder This  disease is a result of the deterioration of structures in the spinal cord that are responsible for transmission of nerve impulses.  The changes may be found anywhere in the spinal cord, they are most severe in the lower back. This disease is found in the older dog It begins with a loss of coordination in the hind limbs. The disease is chronic and progressive, resulting in paralysis.
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Basil’s Test Results shows he is NORMAL and HEALTHY
You can therefore be reassured that your Cockapoo Puppy will Not be affected with Degenerative Myelopahy

Hereditary Nephropathy (COL4A4)

Familial nephropathy (English springer spaniel type) is an inherited disorder of the kidneys affecting dogs. Normally protein is not present in the urine, but in affected dogs there is a defect that allows protein from the blood to be filtered by the kidneys and lost in the urine. Abnormal amounts of protein can be detected in the urine usually between 4-6 months of age. Symptoms of chronic kidney disease begin a few months after excessive protein is noted in the urine. Symptoms of chronic kidney disease include excessive thirst and urination, vomiting, inappetence, weight loss, weakness and fatigue. If drinking excessively, some dogs may also inappropriately urinate in the house or in a crate. Affected dogs typically die of chronic kidney failure by one to two years of age.

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Basil’s Test Results shows he is NORMAL and HEALTHY
You can therefore be reassured that your Cockapoo Puppy will Not Inherit
Hereditary Nephropathy

 


Luxating patella

(or trick knee, subluxation of patella, floating patella or floating kneecap)
is a condition in which the patella or kneecap, dislocates or moves out of its normal location. Patellar luxation is a common condition in dogs particularly small and miniature breeds.
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Bazil has visited the vets and they found him free from
Medial and Lateral Patella Luxation

If you require more information on any of the above Genetic Conditions
There are a lot more indepth articals on the internet